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Silvia Vidal Lab

Lab Info

The laboratory of Silvia Vidal (Departments of Human Genetics, Microbiology/Immunology) investigates the molecular interactions between several human pathogenic viruses and the host innate response to virus infection using mouse genetic models.  Specifically, they address the role of activating natural killer cell receptors in both recognition of the infected cell and regulation of natural killer cell activity during cytomegalovirus infection.  Other topics of the lab are the role of type I-IFN dependent and independent mechanisms that control coxsackievirus-mediated myocarditis, and the genetic basis of the dysregulated inflammatory response leading to influenza pneumonia.  A second goal, as part of a collaborative group, is to establish mouse chemical mutagenesis and large-scale phenotyping to identify defective host resistance in all major classes of microbial pathogens as a means to provide a comprehensive understanding of the key physiologic pathways of protective immunity.

Vidal Lab Contact Information

Contact Information:
Office Phone: (514) 398-2362
Lab Phone:  (514) 398-2360
Fax: (514) 398-2603
Email: silvia.vidal@mcgill.ca

Mailing address:
McGill Life Sciences Complex
Bellini Pavilion, Room 367
3649 Promenade Sir-William Osler
Montreal, Qc, Canada H3G 0B1

Research

Dr. Vidal received her Ph.D. from Université de Genève in 1990. Subsequently, she did post-doctoral training in Dr. P. Gros’s lab at McGill University. In 1995, Dr. Vidal started her career as an Assistant Professor in the Department of Medicine and the Department of Microbiology and Immunology of McGill University. From 1998 to 2003 she was an Assistant Professor and then an Associate Professor at the Department of Biochemistry, Microbiology and Immunology (BMI), University of Ottawa. Since 2003 Dr. Vidal has been an Associate Professor of the Departments of Human Genetics (primary appointment), Microbiology and Immunology, and Medicine of McGill University. Dr. Vidal’s research focus has been in genetic basis and molecular pathogenesis of the host response to infection with viruses. Dr. Vidal has received generous funding from various agencies to support her research including the Canadian Institute of Health Research (CIHR), the Canadian Heart and Stroke Foundation, and the Canadian Genetic Diseases Network (CGDN). During her career, Dr. Vidal has received several prestige honors and awards including Canada Research Chair in host response to viruses and Michael Smith Promising Scientist Award. Dr. Vidal is the Director of CIHR-NET for the Development of New Genetic Models of Infectious Diseases and is the leader for a team of seven research groups. Dr. Vidal has trained a number of post-doctoral fellows, graduate students and undergraduate students. Her laboratory has published more than 60 peer-reviewed papers and review articles, several of them were among the high-impact journals such as Nature Genetics, The Journal of Experimental Medicine, PLOS Pathogens and the Journal of Immunology.

Research Themes

The laboratory of Silvia Vidal (Departments of Human Genetics, Microbiology/Immunology) investigates the molecular interactions between several human pathogenic viruses and the host innate response to virus infection using mouse genetic models. Specifically, they address the role of activating natural killer cell receptors in both recognition of the infected cell and regulation of natural killer cell activity during cytomegalovirus infection. Other topics of the lab are the role of type I-IFN dependent and independent mechanisms that control coxsackievirus-mediated myocarditis, and the genetic basis of the dysregulated inflammatory response leading to influenza pneumonia. A second goal, as part of a collaborative group, is to establish mouse chemical mutagenesis and large-scale phenotyping to identify defective host resistance in all major classes of microbial pathogens as a means to provide a comprehensive understanding of the key physiologic pathways of protective immunity.

Publications

Click HERE to view Dr Vidal’s complete individual publications. 

Personnel

Dr.Silvia Vidal, PhD

Principal investigator, Professor

Dr.Silvia Vidal, PhD

Principal investigator, Professor

Dr.Silvia Vidal, PhD

Principal investigator, Professor

Dr.Silvia Vidal, PhD

Principal investigator, Professor

Dr.Silvia Vidal, PhD

Principal investigator, Professor

Dr.Silvia Vidal, PhD

Principal investigator, Professor

ALUMNI

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Mathieu Mancini

PhD student
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Mathieu Mancini

PhD student
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Mathieu Mancini

PhD student
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Mathieu Mancini

PhD student
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Mathieu Mancini

PhD student
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Mathieu Mancini

PhD student
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Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
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Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student
no profile

Mathieu Mancini

PhD student